Preheat oven to 400 degrees.
Prepare elbow macaroni according to instructions on package. Cook only until al dente (firm). Drain. Set aside.
While elbow macaroni is boiling, prepare ground beef (ground chuck or ground turkey). In a medium skillet over medium heat, cook meat until all of it is brown. Thoroughly drain on paper towels. Set aside.
Evenly coat a 9 x 9 deep baking dish baking dish with 2 tablespoons of melted butter (will use remaining 2 tablespoons later).
Pour in drained elbow macaroni. Top with 1/2 of cooked meat and 1 cup of shredded cheddar cheese and 1 cup of shredded mozzarella/provolone cheese.
Top with remaining cooked meat and remaining 1 cup of shredded cheddar cheese and 1 cup of shredded low-moisture mozzarella/provolone cheese. Set aside.
Pour buttermilk into a medium-sized bowl. Add salt and black pepper (to taste), garlic powder, onion powder, paprika (smoked or regular), 2 tablespoons of melted butter. Stir until well combined.
Pour mixture in center of baking dish. It will spread out evenly as you pour. Cover with foil.
Reduce oven to 375. Bake 12-15 minutes OR until cheese is bubbly. Remove foil. Place under broiler until cheese is lightly browned (optional).
Lightly sprinkle each hot serving with grated or shredded Parmesan cheese.