Preheat oven to 325 degrees.
In large bowl, cream together softened cream cheese, softened butter, and sugar. Use a spoon or hand mixer to beat until smooth and fluffy.
Pour in 1/4 cup buttermilk. Add six eggs one at a time. Beat well after adding each one.
Add flour gradually. Beat until well combined. Stir in vanilla extract. Set aside.
Spray a 12-cup Bundt pan with baking spray that contains flour. OR grease with vegetable oil and lightly dust with all-purpose flour. Shake off excess.
Carefully spoon cake batter into prepared pan.
Bake 1 hour. Remove from oven to check for doneness. Insert long knife all the way to bottom. Remove and check blade. If blade is clean, cake is done. If batter sticks to blade, return to oven and bake 10-15 minutes. Repeat until blade comes out clean.
After baking, allow cake to stand in pan for 10 minutes. Loosen edges with a rubber spatula. Place plate on top of pan. Flip pan over on plate.
Serve warm or cold.
Makes 12-14 servings (depending on size of each slice).